Unravelling the intricacies: The coagulation cascade explained
Tracks
Advanced Clinical Stream - Eureka 1
| Wednesday, March 19, 2025 |
| 1:30 PM - 2:30 PM |
| Eureka 1 |
Overview
Melissa Shoard
Speaker
Melissa Shoard
VCTA, SASH, VNCA
Unravelling the intricacies: The coagulation cascade explained
Abstract
The Coagulation Cascade
The coagulation cascade involves a series of ordered reactions that lead to the controlled generation of thrombin, a key enzyme. Thrombin plays a pivotal role in clot formation by limited proteolysis.
1. Zymogen Activation: At each stage, inactive clotting factors (zymogens) are converted into active proteases through cleavage of peptide bonds.
2. Pathways: There are three pathways:
- Extrinsic: Triggered by tissue factor (factor III) interacting with factor VII.
- Intrinsic: Involves factors XII, XI, IX, and VIII.
- Common: Utilizes factors X, V, II, I, and XIII.
3. Final Common Pathway: Both extrinsic and intrinsic pathways converge to activate factor X, leading to thrombin production.
This lecture will cover the understanding of the coagulation cascade, which is essential for managing thrombosis and maintaining hemostasis. Also, anticoagulant drugs and toxins and a summary of treatment options
The coagulation cascade involves a series of ordered reactions that lead to the controlled generation of thrombin, a key enzyme. Thrombin plays a pivotal role in clot formation by limited proteolysis.
1. Zymogen Activation: At each stage, inactive clotting factors (zymogens) are converted into active proteases through cleavage of peptide bonds.
2. Pathways: There are three pathways:
- Extrinsic: Triggered by tissue factor (factor III) interacting with factor VII.
- Intrinsic: Involves factors XII, XI, IX, and VIII.
- Common: Utilizes factors X, V, II, I, and XIII.
3. Final Common Pathway: Both extrinsic and intrinsic pathways converge to activate factor X, leading to thrombin production.
This lecture will cover the understanding of the coagulation cascade, which is essential for managing thrombosis and maintaining hemostasis. Also, anticoagulant drugs and toxins and a summary of treatment options
Biography
Melissa is an accomplished emergency and critical care (ECC) professional based in Western Sydney, with over a decade of experience in the veterinary industry. She is deeply passionate about training and educating nurses, technicians, and veterinarians, holding notable qualifications such as her VTS (ECC), a Diploma of Veterinary Nursing (ECC), a Certificate IV in Training and Assessing, and proudly being an RVN and AVN.
In addition to being published in the AVNJ and lecturing at conferences, Melissa was honoured with the 2024 Louise O'Dwyer VTS Aspiration Award for her dedication to the field. She actively volunteers with the VNCA at both state and national levels. Recently, she founded the Veterinary Care Training Academy, a platform dedicated to teaching, fostering growth, and supporting the veterinary profession. Always striving to expand her expertise, Melissa is currently pursuing a second diploma in general practice.
